What is an
SRP: Siderophore Receptor and Porin technology
Porins: protein pores in the cell wall that allow essential nutrients to enter the cell
Siderophore receptors: specialized porin proteins that transport iron-siderophore complexes through the cell wall
SRP® technology: siderophore receptor and porin proteins are extracted from the bacterial cell wall and used as vaccine antigens
How does it work
Gram-negative coliforms require iron for growth.
Vaccine creates antibodies to block uptake of iron.
Gram-negative bacteria share similar SRP proteins.
Vaccination is a good tool to be used as part of a whole herd solution with dairy farm management.
The mode of action of SRP® vaccines is different from that of whole-cell autogenous or core antigen vaccines. The SRP® vaccine antibodies bind and block uptake of iron and nutrients through bacterial cell wall pores, starving bacteria of needed nutrients. Since it is designed from siderophore receptors and porins, specialized proteins on the outer membrane of the bacteria, the SRP® vaccine provides strong overall immunity.